No one knows the exact reason why this happens, but all versions of Microsoft Outlook from 2003 to the newest Outlook 2019 may be affected.
A good indication that the file is corrupted is when its size is 0 KB. The main symptom of this problem is very obvious and easily recognizable: you click Outlook's icon, an hourglass appears and is hanging for a while, and then you get the "Cannot start Microsoft Office Outlook" error.Īccording to Microsoft, the major cause of this issue is a corrupted Navigation Pane settings file - profilename.xml, where "profilename" is the name of your Outlook profile. "Unable to start Microsoft Outlook" error - causes and symptoms
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